PhenX - computed tomography (CT) of the abdominal organs protocol 190501

General Details:

Name:: PhenX - computed tomography (CT) of the abdominal organs protocol 190501
Steward:: LOINC
Definition:: This protocol is divided into two parts. Part I consists of abdominal computed tomography (CT) imaging to measure liver fat, or hepatic steatosis. Part II is a secondary analysis and consists of abdominal CT imaging to determine the normal distribution of abdominal organ volumes. Organs are outlined by hand on each CT image by using a computer. The organs studied include left and right kidneys, left and right adrenals, spleen, pancreas, and liver; the first lumbar vertebrae are also studied. This measure exposes participants to radiation, so the risk and benefit need to be considered for each individual. Because of the exposure to radiation, this measure should only be performed on a subject when there is a strong indication to do so. Abdominal computed tomography (CT) scans for upper abdominal disorders (liver, pancreas, gallbladder, spleen, adrenal glands) can be done while shielding the pelvis of potentially childbearing women to reduce risk. The Gastrointestinal Working Group (WG) would also like to note the following: 1. estimates of subcutaneous fat and visceral fat can be made with limited assessment of sections at the L3/4 level (Irlbeck et al., 2010); 2. automated volume estimates can be used (with a couple of references); and 3. electronic images should be stored for secondary analysis of organ-specific measures.
Registration Status:: Qualified

Value	Code Name	Code	Code System	Code Description

Designation:: PhenX - computed tomography (CT) of the abdominal organs protocol 190501
Tags:: Long Common Name

Definition:: This protocol is divided into two parts. Part I consists of abdominal computed tomography (CT) imaging to measure liver fat, or hepatic steatosis. Part II is a secondary analysis and consists of abdominal CT imaging to determine the normal distribution of abdominal organ volumes. Organs are outlined by hand on each CT image by using a computer. The organs studied include left and right kidneys, left and right adrenals, spleen, pancreas, and liver; the first lumbar vertebrae are also studied. This measure exposes participants to radiation, so the risk and benefit need to be considered for each individual. Because of the exposure to radiation, this measure should only be performed on a subject when there is a strong indication to do so. Abdominal computed tomography (CT) scans for upper abdominal disorders (liver, pancreas, gallbladder, spleen, adrenal glands) can be done while shielding the pelvis of potentially childbearing women to reduce risk. The Gastrointestinal Working Group (WG) would also like to note the following: 1. estimates of subcutaneous fat and visceral fat can be made with limited assessment of sections at the L3/4 level (Irlbeck et al., 2010); 2. automated volume estimates can be used (with a couple of references); and 3. electronic images should be stored for secondary analysis of organ-specific measures.
Tags:: Source: Regenstrief LOINC

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Language Code:: en-US
Document:: Fatty Liver/Hepatic Steatosis: Speliotes, E. K., Massaro, J. M., Hoffmann, U., Foster, M. C., Sahani, D. V., Hirschhorn, J. N., O'Donnell, C. J., & Fox, C. J. (2008). Liver fat is reproducibly measured using computed tomography in the Framingham Heart Study. Journal of Gastroenterology and Hepatology, 23(6), 894–899.

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Language Code:: en-US
Document:: Organ Volume: Geraghty, E. M., Boone, J. M., McGahan, J. P., & Jain, K. (2004). Normal organ volume assessment from abdominal CT. Abdominal Imaging, 29(4), 482–490.

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Language Code:: en-US
Document:: Irlbeck, T., Massaro, J. M., Bamberg, F., O'Donnell, C. J., Hoffmann, U., & Fox, C. S. (2010). Association between single-slice measurements of visceral and abdominal subcutaneous adipose tissue with volumetric measurements: The Framingham Heart Study. International Journal of Obesity, 34(4), 781–787.

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Code System	Code	Code Text	Code Version
https://www.phenxtoolkit.org	190501	computed_tomography_(ct)_of_the_abdominal_organs

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Component	Property	Time	System	Scale	Method
PhenX - computed tomography (CT) of the abdominal organs protocol 190501	-	Pt	^Patient	-	PhenX

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Basic Attributes

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Class	Type	First Released	Last Updated	Change Reason
PANEL.PHENX	Clinical	Version 2.36	Version 2.66	Updated the PhenX ID from "PhenX." to "PX" in Survey Question Source field to align with the variable identifier used in the PhenX Toolkit.; Added the PhenX protocol ID to the Component to clearly define the protocol version for which this panel is based upon.